EPITHELIAL tissue (or epithelium =
EP. ).
EP. – is layer of cells
, attached to
BASEMENT MEMBRANE. NO blood
vessels in EP.;
NO extracellular matrix in EP.; Epithelial cell is
POLAR, because it has
3 surfaces with different structure: 1)APICAL surf. It can carry SPECIAL organells: a)
MICROVILLI (in small intestine, kidney) or b)
CILIA (in bronchi, trachea); 2) BASAL surf. It attached to basement membrane; 3) LATERAL surf. By it cells attach each to other with “tight junctions”.
MORPHOLOGIC classification of EP. includes
2 types of EP.:
1)
SIMPLE EP. ( if
ALL cells attach to basement membrane),
2)
STRATIFIED EP. ( if
NOT all cells attach to basement membrane).
SIMPLE epithelia:
1) Simple SQUAMOUS EP. includes
2 types: A) ENDOthelium, B) MESOthelium.
A)
Endothelium lines blood VESSELS, lymph vessels, heart CHAMBERS.
Funct.: It secretes
anticoagulants,
preventing intravascular blood coagulation.
B)
Mesothelium covers surfaces of PLEURA, PERITONEUM, PERICARDIUM.
Funct. It secretes
serous fluid, reducing friction.
2) Simple CUBOIDAL EP. It locates in RENAL tubules. Cells carry MICROVILLI.
Funct. -- is H2O and ions
reabsorption.
3) Simple COLUMNAR EP. It lines mucosa of STOMACH, SMALL intestine, COLON.
Cells in
small intestine carry apical MICROVILLI, collectively named BRUSH BORDER. Funct.:
It participate in TERMINAL digestion and monomers
absorption.
4) Simple COLUMNAR
PSEUDOstratified CILIATED EP. It lines BRONCHI , TRACHEA.
It contains : a) CILIATED cells , b) GOBLET cs., c)BASAL cs.
Ciliated cells are tall columnar cs with apical CILIA. Funct.:
removal of
dust particles.
STRATIFIED epithelia:
1) Stratified squamous
NONkeratinized EP. It lines ORAL cavity (tongue), ESOPHAGUS, CORNEA. It is composed of 3 layers:1)Stratum
basale .(
cuboidal cells with function as origin of
regeneration), 2)Stratum spinosum, 3)Layer of squamous cells. (cs
contain nuclei and
don’t contain protein keratin. Funct. – is
protection).
2) Stratified squamous
KERATINIZED EP. It is in: skin EPIDERMIS, HARD PALATE, GINGIVA, CUTANEOUS ANUS. It has
5 layers: A)Stratum
basale.(contains
cuboidal cells with function as
origin of
REGENERATION, due to active MITOSIS/proliferation), B)Stratum spinosum, C)Stratum granulosum, D)Stratum lucidum, E) Stratum
CORNEUM.
Squamous cells in it
don’t contain nuclei and
contain protein
keratin. Funct. of str. CORNEUM – is
PROTECTION.
3) Stratified
TRANSITIONAL EP. It lines: renal PELVIS, URETER, URINARY bladder, URETHRA.
GLANDS (=
Gs). It are composed of GLANDULAR epithelium.
1)EXOcrine Gs are composed of
2 portions: 1)DUCT, 2)SECRETORY portion (or acinus).
2)ENDOcrine Gs are composed of
1 portion: SECRETORY portion
only. (it are duct
less)
Morphologic classification of EXOcrine Gs:
1)If duct is
NOT branched – gland is SIMPLE. 2)If duct
is branched – gland is COMPOUND.
3)If secretory portion is spherical-shaped – gland is ALVEOLAR. 4) If secretory portion is cylindrrical-shaped – gland is TUBULAR. (for example,
sweat gland – is SIMPLE TUBULAR gl.;
salivary Gs- are COMPOUND TUBULO-ALVEOLAR Gs.
Glandular epithelial cells in SECRETORY portion synthetize and secrete secretory products (sweat, saliva, milk, sebum) into duct, emptying on skin surface or lumen of hollow organs.
Mechanisms of
releasing of secretory products (or
types of secretion) from
glandular epithelial cell:
1)
MEROcrine secretion – when cell portions are
NOT pinched-off into secretory products.
(
parotid salivary Gs)
2)
APOcrine secretion - when APICAL (only) portions of cytoplasm are
pinched-off
into secretory products.
3)
HOLOcrine secretion - when epithelial cell during secretion is COMPLETELY
DESTROYED. (sebaceous Gs
)
Составитель – доцент В.В. Бондаренко.